George Springer, who has spent the last three days on a rehab assignment at Quad Cities, felt something in his quad as he was legging out a double.
"(Springer) hit a double and kind of felt it in his quad so for precautionary reasons we pulled him out of the game," Astros manager Bo Porter said after Wednesday's loss to the Phillies.
There was some hope that if all went well in Quad Cities that Springer could re-join the Astros for their final game in Philadelphia. Instead Porter said Springer would go back to Houston, rest on Thursday and report to Minute Maid Park on Friday.
Springer was hitting .231 with the Astros with 20 home runs and 51 RBIs before he went on the disabled list beginning July 20.
Springer also drew a walk and stole a base in Wednesday's game. He had three walks and two stolen bases for Quad Cities since Monday.